Evaluation of Antidiabetic Potential of Ficus religiosa Leaf Extract in Streptozotocin-Induced Rats

Abstract

Background: It is projected that the incidence of diabetes is rising yearly. Many people, including those in India, which is
regarded as the world's diabetes capital, practice traditional medicine. Disturbances in the metabolism of fats, carbohydrates,
and proteins are hallmarks of diabetes, a metabolic disease. The goal of this research is to assess coriandrum sativum's
potential as an antidiabetic. Linn fruit methanolic extract in a model of diabetic wistar albino rats caused by streptozocin.
Techniques: Streptozocin (50 mg/kg, i.p.) in citrate buffer is used to induce diabetes in wistar albino rats. Five groups (A, B,
C, D, and E) of thirty wistar albino rats were created. Group B was the diabetic control, Group C was the methanolic
coriandrum sativum, and Group D was the normal control. Group E was administered the conventional medication
Glibenclamide (0.5 mg/kg) orally at doses of 100 and 200 mg/kg of Linn. fruits extract (CSFME). Blood sugar levels were
monitored at regular intervals until the study's conclusion, and all groups received treatment for 14 days in a row.
Findings: This investigation demonstrates that the test drug compound CSFME exhibits persistent oral hypoglycemic action
that is statistically significant (p ≤0.05) and equivalent to that of the common medication Glibenclamide. The study's findings
support the antidiabetic effects of CSFME in wistar diabetic albino rats produced by streptozocin. It may be a new
antidiabetic medication and a dietary supplement for the treatment of type 2 diabetes and its complications.