DETERMINANT AND PROTECTOR OF HEPATOSIS IN HIGH- FAT-FED WISTAR RATS

Abstract

Sesamum indicum has a long history of use in traditional medicine; it protects metabolic rats given a high-fat diet and
enhances liver functioning. The current study examined the hepatoprotective effects of sesame meal on Wistar rats who
were given a high-fat diet. A total of five groups of healthy adult male wistar rats were created. Rats in Group I received a
standard laboratory diet (20g/rat/day), rats in Group II received a high-fat diet (20mg/rat/day), rats in Group III received
a combination of 70% high-fat diet and 30% sesame meal (20mg/rat/day), rats in Group IV received pioglitazone (25mg/kg
of body weight) intravenously administered daily, and rats in Group V received a combined mixture of 70% standard
laboratory pellet and 30% sesame meal (20mg/rat/day). Once the trial period (thirteen weeks) came to a close, the rats
were killed. At the conclusion of the trial, rats who were given a high-fat diet showed a considerable rise in both their body
weight and liver weight. While total protein levels declined, AST, ALT, ALP, and bilirubin levels in the blood and liver
tissues of the rats given a high-fat diet increased significantly. However, after being treated with sesame meal, the values of
all parameters returned to a normal range. Findings indicate that sesame meal has a strong hepatoprotective effect on rats
that are given a high-fat diet. In terms of hepato-protective function, comparing the effects of sesame meal therapy to those
of pioglitazone on rats that were given a high-fat diet shows that the sesame meal treatment was almost as effective as the
pioglitazone treatment, if not more so.