Evaluation of Swietenia macrophylla King's (Meliaceae) Seed's Antidiarrheal Activity in Vivo

Abstract

Previous studies have shown that the use of niosomes as drug carriers yields better outcomes than other methods,
especially when it comes to antifungal medications. Pharmaceuticals that are both hydrophilic and hydrophobic
may be encapsulated in niosomes, which also prolongs their stability in circulation. The preparation and
assessment of luliconazole niosomal gel for antifungal activity was the goal of this investigation. The present
investigation included the preparation of luliconazole-containing niosomes by the thin-film hydration process,
employing non-ionic surfactants (Span 60 and Tween 80) and cholesterol at varying concentrations. The
produced formulations underwent evaluations for stability tests, in-vitro drug release investigations, drug
content, drug entrapment efficiency, and optical microscopy. Better outcomes were shown when the ratio of
cholesterol to span 60 was 2:1. It was thus refined to become the ultimate vesicle formulation. According to the
results of the FTIR analysis, luliconazole and any of the excipients did not interact. The niosomes gel was
assessed across all formulations for a number of criteria. The most favorable and encouraging outcomes are seen
with the 1% Carbopol 934 gel. To improve transdermal effectiveness, the niosomal gel formulation may prove to
be a helpful dose form.